Explore how our research has advanced the field of genomics, precision medicine, and targeted therapies.
Machine Learning Target Prediction
CRISPR High-Fidelity Cleavage
Phase II Efficacy Study
From In-Vitro to Animal Models in 6 months
Long-term Expression Stability
Deep Learning Structures
Gene Silencing Therapies
Targeted Tissue Penetration
Nova Institute of Health
3 Years
In-Silico Modeling, Cell Assay, NGS
Existing Cas9 effectors exhibited high off-target cleavage rates, leading to unwanted mutations in therapeutic applications.
We needed a predictive model that optimized sgRNA design to maintain high on-target efficacy while reducing off-target binding to near zero.
Reduction in off-target effects
On-target cleavage efficiency
Faster screening pipeline
